Network model‐based screen for FDA‐approved drugs affecting cardiac fibrosis

Cardiac fibrosis is a significant component of pathological heart remodeling, yet it is not directly targeted by existing drugs. Systems pharmacology approaches have the potential to provide mechanistic frameworks with which to predict and understand how drugs modulate biological systems. Here, we c...

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Bibliografiske detaljer
Udgivet i:CPT Pharmacometrics Syst Pharmacol
Main Authors: Zeigler, Angela C., Chandrabhatla, Anirudha S., Christiansen, Steven L., Nelson, Anders R., Holmes, Jeffrey W., Saucerman, Jeffrey J.
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2021
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8099443/
https://ncbi.nlm.nih.gov/pubmed/33571402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/psp4.12599
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