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Computational Model Predicts Paracrine and Intracellular Drivers of Fibroblast Phenotype After Myocardial Infarction

The fibroblast is a key mediator of wound healing in the heart and other organs, yet how it integrates multiple time-dependent paracrine signals to control extracellular matrix synthesis has been difficult to study in vivo. Here, we extended a computational model to simulate the dynamics of fibrobla...

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Detalhes bibliográficos
Publicado no:Matrix Biol
Main Authors: Zeigler, Angela C., Nelson, Anders R., Chandrabhatla, Anirudha S., Brazhkina, Olga, Holmes, Jeffrey W., Saucerman, Jeffrey J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7434705/
https://ncbi.nlm.nih.gov/pubmed/32209358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.matbio.2020.03.007
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