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A computational model of cardiac fibroblast signaling predicts context-dependent drivers of myofibroblast differentiation

Cardiac fibroblasts support heart function, and aberrant fibroblast signaling can lead to fibrosis and cardiac dysfunction. Yet how signaling molecules drive myofibroblast differentiation and fibrosis in the complex signaling environment of cardiac injury remains unclear. We developed a large-scale...

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Detalhes bibliográficos
Publicado no:J Mol Cell Cardiol
Main Authors: Zeigler, A.C., Richardson, W. J., Holmes, J. W., Saucerman, J. J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4861657/
https://ncbi.nlm.nih.gov/pubmed/27017945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2016.03.008
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