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Microtubule-sliding modules based on kinesins EG5 and PRC1-dependent KIF4A drive human spindle elongation

Proper chromosome segregation into two future daughter cells requires the mitotic spindle to elongate in anaphase. However, although some candidate proteins are implicated in this process, the molecular mechanism that drives spindle elongation in human cells is unknown. Using combined depletion and...

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Publicado en:Dev Cell
Autores principales: Vukušić, Kruno, Ponjavić, Ivana, Buđa, Renata, Risteski, Patrik, Tolić, Iva M.
Formato: Artigo
Lenguaje:Inglês
Publicado: Cell Press 2021
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8098747/
https://ncbi.nlm.nih.gov/pubmed/33910056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2021.04.005
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