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Catalytic mechanism of the colistin resistance protein MCR-1
The mcr-1 gene encodes a membrane-bound Zn(2+)-metalloenzyme, MCR-1, which catalyses phosphoethanolamine transfer onto bacterial lipid A, making bacteria resistant to colistin, a last-resort antibiotic. Mechanistic understanding of this process remains incomplete. Here, we investigate possible catal...
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| Publicado no: | Org Biomol Chem |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Royal Society of Chemistry
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8097703/ https://ncbi.nlm.nih.gov/pubmed/33606866 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d0ob02566f |
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