Catalytic mechanism of the colistin resistance protein MCR-1

The mcr-1 gene encodes a membrane-bound Zn(2+)-metalloenzyme, MCR-1, which catalyses phosphoethanolamine transfer onto bacterial lipid A, making bacteria resistant to colistin, a last-resort antibiotic. Mechanistic understanding of this process remains incomplete. Here, we investigate possible catal...

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Bibliographic Details
Published in:Org Biomol Chem
Main Authors: Suardíaz, Reynier, Lythell, Emily, Hinchliffe, Philip, van der Kamp, Marc, Spencer, James, Fey, Natalie, Mulholland, Adrian J.
Format: Artigo
Language:Inglês
Published: The Royal Society of Chemistry 2021
Subjects:
Chemistry
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8097703/
https://ncbi.nlm.nih.gov/pubmed/33606866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d0ob02566f
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