Insights into the Mechanistic Basis of Plasmid-Mediated Colistin Resistance from Crystal Structures of the Catalytic Domain of MCR-1

The polymixin colistin is a “last line” antibiotic against extensively-resistant Gram-negative bacteria. Recently, the mcr-1 gene was identified as a plasmid-mediated resistance mechanism in human and animal Enterobacteriaceae, with a wide geographical distribution and many producer strains resistan...

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Publicado no:Sci Rep
Main Authors: Hinchliffe, Philip, Yang, Qiu E., Portal, Edward, Young, Tom, Li, Hui, Tooke, Catherine L., Carvalho, Maria J., Paterson, Neil G., Brem, Jürgen, Niumsup, Pannika R., Tansawai, Uttapoln, Lei, Lei, Li, Mei, Shen, Zhangqi, Wang, Yang, Schofield, Christopher J., Mulholland, Adrian J, Shen, Jianzhong, Fey, Natalie, Walsh, Timothy R., Spencer, James
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5216409/
https://ncbi.nlm.nih.gov/pubmed/28059088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep39392
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