Insights into the Mechanistic Basis of Plasmid-Mediated Colistin Resistance from Crystal Structures of the Catalytic Domain of MCR-1

The polymixin colistin is a “last line” antibiotic against extensively-resistant Gram-negative bacteria. Recently, the mcr-1 gene was identified as a plasmid-mediated resistance mechanism in human and animal Enterobacteriaceae, with a wide geographical distribution and many producer strains resistan...

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書誌詳細
出版年:Sci Rep
主要な著者: Hinchliffe, Philip, Yang, Qiu E., Portal, Edward, Young, Tom, Li, Hui, Tooke, Catherine L., Carvalho, Maria J., Paterson, Neil G., Brem, Jürgen, Niumsup, Pannika R., Tansawai, Uttapoln, Lei, Lei, Li, Mei, Shen, Zhangqi, Wang, Yang, Schofield, Christopher J., Mulholland, Adrian J, Shen, Jianzhong, Fey, Natalie, Walsh, Timothy R., Spencer, James
フォーマット: Artigo
言語:Inglês
出版事項: Nature Publishing Group 2017
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5216409/
https://ncbi.nlm.nih.gov/pubmed/28059088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep39392
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