Balancing mcr-1 expression and bacterial survival is a delicate equilibrium between essential cellular defence mechanisms

MCR-1 is a lipid A modifying enzyme that confers resistance to the antibiotic colistin. Here, we analyse the impact of MCR-1 expression on E. coli morphology, fitness, competitiveness, immune stimulation and virulence. Increased expression of mcr-1 results in decreased growth rate, cell viability, c...

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Publicado en:Nat Commun
Main Authors: Yang, Qiue, Li, Mei, Spiller, Owen B., Andrey, Diego O., Hinchliffe, Philip, Li, Hui, MacLean, Craig, Niumsup, Pannika, Powell, Lydia, Pritchard, Manon, Papkou, Andrei, Shen, Yingbo, Portal, Edward, Sands, Kirsty, Spencer, James, Tansawai, Uttapoln, Thomas, David, Wang, Shaolin, Wang, Yang, Shen, Jianzhong, Walsh, Timothy
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2017
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5727292/
https://ncbi.nlm.nih.gov/pubmed/29233990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-02149-0
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