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Balancing mcr-1 expression and bacterial survival is a delicate equilibrium between essential cellular defence mechanisms
MCR-1 is a lipid A modifying enzyme that confers resistance to the antibiotic colistin. Here, we analyse the impact of MCR-1 expression on E. coli morphology, fitness, competitiveness, immune stimulation and virulence. Increased expression of mcr-1 results in decreased growth rate, cell viability, c...
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| Опубликовано в: : | Nat Commun |
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| Главные авторы: | , , , , , , , , , , , , , , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Nature Publishing Group UK
2017
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5727292/ https://ncbi.nlm.nih.gov/pubmed/29233990 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-02149-0 |
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