Balancing mcr-1 expression and bacterial survival is a delicate equilibrium between essential cellular defence mechanisms

MCR-1 is a lipid A modifying enzyme that confers resistance to the antibiotic colistin. Here, we analyse the impact of MCR-1 expression on E. coli morphology, fitness, competitiveness, immune stimulation and virulence. Increased expression of mcr-1 results in decreased growth rate, cell viability, c...

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Опубликовано в: :Nat Commun
Главные авторы: Yang, Qiue, Li, Mei, Spiller, Owen B., Andrey, Diego O., Hinchliffe, Philip, Li, Hui, MacLean, Craig, Niumsup, Pannika, Powell, Lydia, Pritchard, Manon, Papkou, Andrei, Shen, Yingbo, Portal, Edward, Sands, Kirsty, Spencer, James, Tansawai, Uttapoln, Thomas, David, Wang, Shaolin, Wang, Yang, Shen, Jianzhong, Walsh, Timothy
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group UK 2017
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5727292/
https://ncbi.nlm.nih.gov/pubmed/29233990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-02149-0
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