Structural and Biochemical Characterization of the Novel CTX-M-151 Extended-Spectrum β-Lactamase and Its Inhibition by Avibactam

The diazabicyclooctane (DBO) inhibitor avibactam (AVI) reversibly inactivates most serine β-lactamases, including the CTX-M β-lactamases. Currently, more than 230 unique CTX-M members distributed in five clusters with less than 5% amino acid sequence divergence within each group have been described....

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Bibliographic Details
Published in:Antimicrob Agents Chemother
Main Authors: Ghiglione, Barbara, Rodríguez, María Margarita, Brunetti, Florencia, Papp-Wallace, Krisztina M., Yoshizumi, Ayumi, Ishii, Yoshikazu, Bonomo, Robert A., Gutkind, Gabriel, Klinke, Sebastián, Power, Pablo
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2021
Subjects:
Mechanisms of Resistance
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8097472/
https://ncbi.nlm.nih.gov/pubmed/33431411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01757-20
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