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Synergistic Rifabutin and Colistin Reduce Emergence of Resistance When Treating Acinetobacter baumannii

Recently, we reported rifabutin hyperactivity against Acinetobacter baumannii. We sought to characterize potential interactions between rifabutin and colistin, the last-resort drug for carbapenem-resistant infections. Rifabutin and colistin were synergistic in vitro and in vivo, and low-dose colisti...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Cheng, Jiaqi, Yan, Jun, Reyna, Zeferino, Slarve, Matt, Lu, Peggy, Spellberg, Brad, Luna, Brian
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8097462/
https://ncbi.nlm.nih.gov/pubmed/33468472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02204-20
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