E3 ubiquitin ligase NEDD4L negatively regulates keratinocyte hyperplasia by promoting GP130 degradation

Psoriasis is mainly characterized by abnormal hyperplasia of keratinocytes and immune cells infiltrating into the dermis and epidermis. Neural precursor cell expressed developmentally downregulated 4‐like (NEDD4L) is a highly conserved HECT type E3 ligase that plays an important role in regulating p...

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Bibliographic Details
Published in:EMBO Rep
Main Authors: Liu, Huan, Lin, Wenlong, Liu, Zhiyong, Song, Yinjing, Cheng, Hao, An, Huazhang, Wang, Xiaojian
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2021
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8097351/
https://ncbi.nlm.nih.gov/pubmed/33769697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.202052063
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