Temporal analysis of T-cell receptor-imposed forces via quantitative single molecule FRET measurements

Mechanical forces acting on ligand-engaged T-cell receptors (TCRs) have previously been implicated in T-cell antigen recognition, yet their magnitude, spread, and temporal behavior are still poorly defined. We here report a FRET-based sensor equipped either with a TCR-reactive single chain antibody...

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Библиографические подробности
Опубликовано в: :Nat Commun
Главные авторы: Göhring, Janett, Kellner, Florian, Schrangl, Lukas, Platzer, René, Klotzsch, Enrico, Stockinger, Hannes, Huppa, Johannes B., Schütz, Gerhard J.
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group UK 2021
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC8096839/
https://ncbi.nlm.nih.gov/pubmed/33947864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-22775-z
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