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Improved Ligand Discrimination by Force-Induced Unbinding of the T Cell Receptor from Peptide-MHC

T cell activation is mediated via the recognition of peptides by the T cell receptor (TCR). This receptor ligand interaction is highly specific, and the TCR has to discriminate between a huge number of peptides presented by the products of the major histocompatibility complexes (MHCs). Recent studie...

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Bibliografiske detaljer
Main Authors: Klotzsch, Enrico, Schütz, Gerhard J.
Format: Artigo
Sprog:Inglês
Udgivet: The Biophysical Society 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3628311/
https://ncbi.nlm.nih.gov/pubmed/23601314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2013.03.023
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