Monomeric TCRs Drive T-Cell Antigen Recognition

T-cell antigen recognition requires T-cell antigen receptors (TCRs) binding to MHC-embedded antigenic peptides (pMHCs) within the contact region of a T-cell with its conjugated antigen-presenting cell. Despite micromolar TCR:pMHC affinities, T-cells respond to even a single antigenic pMHC, and highe...

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Detalhes bibliográficos
Publicado no:Nat Immunol
Main Authors: Brameshuber, Mario, Kellner, Florian, Rossboth, Benedikt K., Ta, Haisen, Alge, Kevin, Sevcsik, Eva, Göhring, Janett, Axmann, Markus, Baumgart, Florian, Gascoigne, Nicholas R. J., Davis, Simon J., Stockinger, Hannes, Schütz, Gerhard J., Huppa, Johannes B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7612939/
https://ncbi.nlm.nih.gov/pubmed/29662172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41590-018-0092-4
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