Loss of Sarcomeric Proteins via Upregulation of JAK/STAT Signaling Underlies Interferon-γ-induced Contractile Deficit in Engineered Human Myocardium

The level of circulating interferon-γ (IFNγ) is elevated in various clinical conditions including autoimmune and inflammatory diseases, sepsis, acute coronary syndrome, and viral infections. As these conditions are associated with high risk of myocardial dysfunction, we investigated the effects of I...

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Bibliographic Details
Published in:	Acta Biomater
Main Authors:	Zhan, Ren-Zhi, Rao, Lingjun, Chen, Zhaowei, Strash, Nicholas, Bursac, Nenad
Format:	Artigo
Language:	Inglês
Published:	2021
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC8096718/ https://ncbi.nlm.nih.gov/pubmed/33705988 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.actbio.2021.03.007
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Loss of Sarcomeric Proteins via Upregulation of JAK/STAT Signaling Underlies Interferon-γ-induced Contractile Deficit in Engineered Human Myocardium

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