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Loss of Sarcomeric Proteins via Upregulation of JAK/STAT Signaling Underlies Interferon-γ-induced Contractile Deficit in Engineered Human Myocardium
The level of circulating interferon-γ (IFNγ) is elevated in various clinical conditions including autoimmune and inflammatory diseases, sepsis, acute coronary syndrome, and viral infections. As these conditions are associated with high risk of myocardial dysfunction, we investigated the effects of I...
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| Publicat a: | Acta Biomater |
|---|---|
| Autors principals: | , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2021
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8096718/ https://ncbi.nlm.nih.gov/pubmed/33705988 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.actbio.2021.03.007 |
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