OSU-03012 Disrupts Akt Signaling and Prevents Endometrial Carcinoma Progression in vitro and in vivo

PURPOSE: OSU-03012 is a celecoxib derivative lacking cyclooxygenase-2 inhibitory activity and a potent PDK1 inhibitor which has been shown to inhibit tumor growth in various ways. However, the role of OSU-03012 in endometrial carcinoma (EC) in which the PI3K/Akt signaling pathway highly activated ha...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Drug Des Devel Ther
Main Authors: Ding, Leilei, Ren, Chenchen, Yang, Li, Wu, Zimeng, Li, Feiyan, Jiang, Dongyuan, Zhu, Yuanhang, Lu, Jie
Format: Artigo
Jezik:Inglês
Izdano: Dove 2021
Teme:
Original Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8096345/
https://ncbi.nlm.nih.gov/pubmed/33958857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S304128
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