Targeting ER Stress and Akt with OSU-03012 and Gefitinib or Erlotinib to Overcome Resistance to EGFR Inhibitors

Pre-existing and acquired resistance to epidermal growth factor receptor (EGFR) inhibitors limit their clinical usefulness in patients with advanced non-small cell lung cancer (NSCLC). This study characterizes the efficacy and mechanisms of the combination of gefitinib or erlotinib with OSU-03012, a...

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Detalhes bibliográficos
Main Authors: Wang, Yu-Chieh, Kulp, Samuel K., Wang, Dasheng, Yang, Chih-Cheng, Sargeant, Aaron M., Hung, Jui-Hsiang, Kashida, Yoko, Yamaguchi, Mamoru, Chang, Geen-Dong, Chen, Ching-Shih
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3904349/
https://ncbi.nlm.nih.gov/pubmed/18413750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-07-1336
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