Selective inhibition of glycogen synthase kinase 3α corrects pathophysiology in a mouse model of fragile X syndrome

Fragile X syndrome is caused by FMR1 gene silencing and loss of the encoded fragile X mental retardation protein (FMRP), which binds to mRNA and regulates translation. Studies in the Fmr1(−/y) mouse model of fragile X syndrome indicate that aberrant cerebral protein synthesis downstream of metabotro...

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Publicado no:Sci Transl Med
Main Authors: McCamphill, Patrick K., Stoppel, Laura J., Senter, Rebecca K., Lewis, Michael C., Heynen, Arnold J., Stoppel, David C., Sridhar, Vinay, Collins, Katie A., Shi, Xi, Pan, Jen Q., Madison, Jon, Cottrell, Jeffrey R., Huber, Kimberly M., Scolnick, Edward M., Holson, Edward B., Wagner, Florence F., Bear, Mark F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8095719/
https://ncbi.nlm.nih.gov/pubmed/32434848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aam8572
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