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β-arrestin2 couples metabotropic glutamate receptor 5 to neuronal protein synthesis and is a potential target to treat fragile X
Synaptic protein synthesis is essential for modification of the brain by experience and is aberrant in several genetically-defined disorders, notably fragile X, a heritable cause of autism and intellectual disability. Neural activity directs local protein synthesis via activation of metabotropic glu...
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| Pubblicato in: | Cell Rep |
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| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5391046/ https://ncbi.nlm.nih.gov/pubmed/28329674 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.02.075 |
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