Effect of Difference in Consensus Sequence between HIV-1 Subtype A/E and Subtype B Viruses on Elicitation of Gag-Specific CD8(+) T Cells and Accumulation of HLA-Associated Escape Mutations

The Gag280 mutation is associated with HLA-C*01:02 but not with HLA-B*52:01 in subtype A/E-infected individuals, whereas this mutation is associated with HLA-B*52:01 but not with HLA-C*01:02 in subtype B infections. Although it is known that the Gag280 mutant is selected by HLA-B*52:01-restricted Ga...

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Udgivet i:J Virol
Main Authors: Zhang, Yu, Murakoshi, Hayato, Chikata, Takayuki, Akahoshi, Tomohiro, Tran, Giang Van, Nguyen, Trung Vu, Gatanaga, Hiroyuki, Nguyen, Kinh Van, Oka, Shinichi, Kuse, Nozomi, Takiguchi, Masafumi
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2021
Fag:
Pathogenesis and Immunity
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8094948/
https://ncbi.nlm.nih.gov/pubmed/33361435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02061-20
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