Functional mechanisms of MYRF DNA-binding domain mutations implicated in birth defects

Myrf is a pleiotropic membrane-bound transcription factor that plays critical roles in diverse organisms, including in oligodendrocyte differentiation, embryonic development, molting, and synaptic plasticity. Upon autolytic cleavage, the Myrf N-terminal fragment enters the nucleus as a homo-trimer a...

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Bibliographische Detailangaben
Veröffentlicht in:J Biol Chem
Hauptverfasser: Fan, Chuandong, An, Hongjoo, Sharif, Mohamed, Kim, Dongkyeong, Park, Yungki
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2021
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8094900/
https://ncbi.nlm.nih.gov/pubmed/33798553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100612
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