Common Polymorphisms in the MDM2 and TP53 Genes and the Relationship between TP53 Mutations and Patient Outcomes in Glioblastomas

MDM2 SNP309 is associated with younger age of tumor onset in patients with Li‐Fraumeni syndrome, and TP53 codon 72 polymorphism decreases its apoptotic potential. Glioblastomas frequently show genetic alterations in the TP53 pathway. In the present study, we assessed MDM2 SNP309 in 360 glioblastomas...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Brain Pathol
Hauptverfasser: Zawlik, Izabela, Kita, Daisuke, Vaccarella, Salvatore, Mittelbronn, Michel, Franceschi, Silvia, Ohgaki, Hiroko
Format: Artigo
Sprache:Inglês
Veröffentlicht: Blackwell Publishing Ltd 2008
Schlagworte:
Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8094731/
https://ncbi.nlm.nih.gov/pubmed/18462472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1750-3639.2008.00170.x
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