TP53 Promoter Methylation in Primary Glioblastoma: Relationship with TP53 mRNA and Protein Expression and Mutation Status

Reduced expression of TP53 by promoter methylation has been reported in several neoplasms. It remains unclear whether TP53 promoter methylation is associated with reduced transcriptional and protein expression in glioblastoma (GB). The aim of our work was to study the impact of TP53 methylation and...

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Bibliographische Detailangaben
Hauptverfasser: Jesionek-Kupnicka, Dorota, Szybka, Malgorzata, Malachowska, Beata, Fendler, Wojciech, Potemski, Piotr, Piaskowski, Sylwester, Jaskolski, Dariusz, Papierz, Wielislaw, Skowronski, Wieslaw, Och, Waldemar, Kordek, Radzislaw, Zawlik, Izabela
Format: Artigo
Sprache:Inglês
Veröffentlicht: Mary Ann Liebert, Inc. 2014
Schlagworte:
Protein Expression/Modification/Regulation
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3967380/
https://ncbi.nlm.nih.gov/pubmed/24506545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/dna.2013.2201
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