MiR-21, miR-34a, miR-125b, miR-181d and miR-648 levels inversely correlate with MGMT and TP53 expression in primary glioblastoma patients

INTRODUCTION: TP53 and MGMT alterations play a crucial role in glioblastoma (GB) pathogenesis. TP53 and MGMT function is affected by several pathologic mechanisms, such as point mutations or promoter methylation, which are well characterized. Expression of both genes can be regulated by other mechan...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Arch Med Sci
Hauptverfasser: Jesionek-Kupnicka, Dorota, Braun, Marcin, Trąbska-Kluch, Berenika, Czech, Joanna, Szybka, Małgorzata, Szymańska, Bożena, Kulczycka-Wojdala, Dominika, Bieńkowski, Michał, Kordek, Radzisław, Zawlik, Izabela
Format: Artigo
Sprache:Inglês
Veröffentlicht: Termedia Publishing House 2017
Schlagworte:
Basic Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6425218/
https://ncbi.nlm.nih.gov/pubmed/30899304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5114/aoms.2017.69374
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