MiR-21, miR-34a, miR-125b, miR-181d and miR-648 levels inversely correlate with MGMT and TP53 expression in primary glioblastoma patients

INTRODUCTION: TP53 and MGMT alterations play a crucial role in glioblastoma (GB) pathogenesis. TP53 and MGMT function is affected by several pathologic mechanisms, such as point mutations or promoter methylation, which are well characterized. Expression of both genes can be regulated by other mechan...

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Detalhes bibliográficos
Publicado no:Arch Med Sci
Principais autores: Jesionek-Kupnicka, Dorota, Braun, Marcin, Trąbska-Kluch, Berenika, Czech, Joanna, Szybka, Małgorzata, Szymańska, Bożena, Kulczycka-Wojdala, Dominika, Bieńkowski, Michał, Kordek, Radzisław, Zawlik, Izabela
Formato: Artigo
Idioma:Inglês
Publicado em: Termedia Publishing House 2017
Assuntos:
Basic Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6425218/
https://ncbi.nlm.nih.gov/pubmed/30899304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5114/aoms.2017.69374
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