Common Polymorphisms in the MDM2 and TP53 Genes and the Relationship between TP53 Mutations and Patient Outcomes in Glioblastomas

MDM2 SNP309 is associated with younger age of tumor onset in patients with Li‐Fraumeni syndrome, and TP53 codon 72 polymorphism decreases its apoptotic potential. Glioblastomas frequently show genetic alterations in the TP53 pathway. In the present study, we assessed MDM2 SNP309 in 360 glioblastomas...

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Detalhes bibliográficos
Publicado no:Brain Pathol
Main Authors: Zawlik, Izabela, Kita, Daisuke, Vaccarella, Salvatore, Mittelbronn, Michel, Franceschi, Silvia, Ohgaki, Hiroko
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2008
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8094731/
https://ncbi.nlm.nih.gov/pubmed/18462472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1750-3639.2008.00170.x
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