Effects of MDM2, MDM4 and TP53 Codon 72 Polymorphisms on Cancer Risk in a Cohort Study of Carriers of TP53 Germline Mutations

BACKGROUND: Previous studies have shown that MDM2 SNP309 and p53 codon 72 have modifier effects on germline P53 mutations, but those studies relied on case-only studies with small sample sizes. The impact of MDM4 polymorphism on tumor onset in germline mutation carriers has not previously been studi...

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Detalhes bibliográficos
Main Authors: Fang, Shenying, Krahe, Ralf, Lozano, Guillermina, Han, Younghun, Chen, Wei, Post, Sean M., Zhang, Baili, Wilson, Charmaine D., Bachinski, Linda L., Strong, Louise C., Amos, Christopher I.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2877078/
https://ncbi.nlm.nih.gov/pubmed/20520810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0010813
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