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Selective Inhibition of Early—but Not Late—Expressed HIF‐1α Is Neuroprotective in Rats after Focal Ischemic Brain Damage

The expression of hypoxia‐inducible factor‐1‐alpha (HIF‐1α) is upregulated in ischemic stroke, but its function is still unclear. In the present study, biphasic expression of HIF‐1α was observed during 1–12 h and after 48 h in neurons exposed to ischemic stress in vitro and in vivo. Treating neurons...

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Detalhes bibliográficos
Publicado no:Brain Pathol
Main Authors: Yeh, Shiu‐Hwa, Ou, Li‐Chin, Gean, Po‐Wu, Hung, Jan‐Jong, Chang, Wen‐Chang
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8094320/
https://ncbi.nlm.nih.gov/pubmed/21029239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1750-3639.2010.00443.x
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