Translational and transcriptional control of Sp1 against ischaemia through a hydrogen peroxide-activated internal ribosomal entry site pathway

The exact mechanism underlying increases in Sp1 and the physiological consequences thereafter remains unknown. In rat primary cortical neurons, oxygen-glucose deprivation (OGD) causes an increase in H(2)O(2) as well as Sp1 in early ischaemia but apparently does not change mRNA level or Sp1 stability...

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Detalhes bibliográficos
Main Authors: Yeh, Shiu Hwa, Yang, Wen Bin, Gean, Po Wu, Hsu, Chung Yi, Tseng, Joseph T., Su, Tsung Ping, Chang, Wen Chang, Hung, Jan Jong
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2011
Assuntos:
Gene Regulation, Chromatin and Epigenetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3141265/
https://ncbi.nlm.nih.gov/pubmed/21441538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr161
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