Morphine drives internal ribosome entry site-mediated hnRNP K translation in neurons through opioid receptor-dependent signaling

Heterogeneous nuclear ribonucleoprotein K (hnRNP K) binds to the promoter region of mu-opioid receptor (MOR) to regulate its transcriptional activity. How hnRNP K contributes to the analgesic effects of morphine, however, is largely unknown. We provide evidence that morphine increases hnRNP K protei...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Lee, Pin-Tse, Chao, Po-Kuan, Ou, Li-Chin, Chuang, Jian-Ying, Lin, Yen-Chang, Chen, Shu-Chun, Chang, Hsiao-Fu, Law, Ping-Yee, Loh, Horace H., Chao, Yu-Sheng, Su, Tsung-Ping, Yeh, Shiu-Hwa
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
Assuntos:
Gene regulation, Chromatin and Epigenetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4245930/
https://ncbi.nlm.nih.gov/pubmed/25361975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku1016
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