Chronic interleukin-1 exposure triggers selection for Cebpa-knockout multipotent hematopoietic progenitors

The early events that drive myeloid oncogenesis are not well understood. Most studies focus on the cell-intrinsic genetic changes and how they impact cell fate decisions. We consider how chronic exposure to the proinflammatory cytokine, interleukin-1β (IL-1β), impacts Cebpa-knockout hematopoietic st...

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Publicat a:J Exp Med
Autors principals: Higa, Kelly C., Goodspeed, Andrew, Chavez, James S., De Dominici, Marco, Danis, Etienne, Zaberezhnyy, Vadym, Rabe, Jennifer L., Tenen, Daniel G., Pietras, Eric M., DeGregori, James
Format: Artigo
Idioma:Inglês
Publicat: Rockefeller University Press 2021
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8094119/
https://ncbi.nlm.nih.gov/pubmed/33914855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20200560
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