Collagen IV(α345) dysfunction in glomerular basement membrane diseases. II. Crystal structure of the α345 hexamer

Our recent work identified a genetic variant of the α345 hexamer of the collagen IV scaffold that is present in patients with glomerular basement membrane diseases, Goodpasture’s disease (GP) and Alport syndrome (AS), and phenocopies of AS in knock-in mice. To understand the context of this “Zurich”...

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Publicat a:J Biol Chem
Autors principals: Boudko, Sergei P., Bauer, Ryan, Chetyrkin, Sergei V., Ivanov, Sergey, Smith, Jarrod, Voziyan, Paul A., Hudson, Billy G.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2021
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8093946/
https://ncbi.nlm.nih.gov/pubmed/33775698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100591
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