Collagen IV(α345) dysfunction in glomerular basement membrane diseases. II. Crystal structure of the α345 hexamer

Our recent work identified a genetic variant of the α345 hexamer of the collagen IV scaffold that is present in patients with glomerular basement membrane diseases, Goodpasture’s disease (GP) and Alport syndrome (AS), and phenocopies of AS in knock-in mice. To understand the context of this “Zurich”...

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Библиографические подробности
Опубликовано в: :J Biol Chem
Главные авторы: Boudko, Sergei P., Bauer, Ryan, Chetyrkin, Sergei V., Ivanov, Sergey, Smith, Jarrod, Voziyan, Paul A., Hudson, Billy G.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2021
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC8093946/
https://ncbi.nlm.nih.gov/pubmed/33775698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100591
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