Collagen IV(α345) dysfunction in glomerular basement membrane diseases. II. Crystal structure of the α345 hexamer

Our recent work identified a genetic variant of the α345 hexamer of the collagen IV scaffold that is present in patients with glomerular basement membrane diseases, Goodpasture’s disease (GP) and Alport syndrome (AS), and phenocopies of AS in knock-in mice. To understand the context of this “Zurich”...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Boudko, Sergei P., Bauer, Ryan, Chetyrkin, Sergei V., Ivanov, Sergey, Smith, Jarrod, Voziyan, Paul A., Hudson, Billy G.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2021
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8093946/
https://ncbi.nlm.nih.gov/pubmed/33775698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100591
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