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Collagen IV(α345) dysfunction in glomerular basement membrane diseases. II. Crystal structure of the α345 hexamer

Our recent work identified a genetic variant of the α345 hexamer of the collagen IV scaffold that is present in patients with glomerular basement membrane diseases, Goodpasture’s disease (GP) and Alport syndrome (AS), and phenocopies of AS in knock-in mice. To understand the context of this “Zurich”...

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Bibliografiset tiedot
Julkaisussa:J Biol Chem
Päätekijät: Boudko, Sergei P., Bauer, Ryan, Chetyrkin, Sergei V., Ivanov, Sergey, Smith, Jarrod, Voziyan, Paul A., Hudson, Billy G.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Biochemistry and Molecular Biology 2021
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC8093946/
https://ncbi.nlm.nih.gov/pubmed/33775698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100591
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