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Collagen IV(α345) dysfunction in glomerular basement membrane diseases. III. A functional framework for α345 hexamer assembly
We identified a genetic variant, an 8-residue appendage, of the α345 hexamer of collagen IV present in patients with glomerular basement membrane diseases, Goodpasture’s disease and Alport syndrome, and determined the long-awaited crystal structure of the hexamer. We sought to elucidate how variants...
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| 出版年: | J Biol Chem |
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| 主要な著者: | , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society for Biochemistry and Molecular Biology
2021
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8099640/ https://ncbi.nlm.nih.gov/pubmed/33775696 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100592 |
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