Cancer of unknown primary stem-like cells model multi-organ metastasis and unveil liability to MEK inhibition

Cancers of unknown primary (CUPs), featuring metastatic dissemination in the absence of a primary tumor, are a biological enigma and a fatal disease. We propose that CUPs are a distinct, yet unrecognized, pathological entity originating from stem-like cells endowed with peculiar and shared propertie...

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Bibliografiske detaljer
Udgivet i:Nat Commun
Main Authors: Verginelli, Federica, Pisacane, Alberto, Gambardella, Gennaro, D’Ambrosio, Antonio, Candiello, Ermes, Ferrio, Marco, Panero, Mara, Casorzo, Laura, Benvenuti, Silvia, Cascardi, Eliano, Senetta, Rebecca, Geuna, Elena, Ballabio, Andrea, Montemurro, Filippo, Sapino, Anna, Comoglio, Paolo M., Boccaccio, Carla
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8093243/
https://ncbi.nlm.nih.gov/pubmed/33941777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-22643-w
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