CD4(+) T cells require Ikaros to inhibit their differentiation toward a pathogenic cell fate

The production of proinflammatory cytokines, particularly granulocyte-macrophage colony-stimulating factor (GM-CSF), by pathogenic CD4(+) T cells is central for mediating tissue injury in inflammatory and autoimmune diseases. However, the factors regulating the T cell pathogenic gene expression prog...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Bernardi, Chiara, Maurer, Gaëtan, Ye, Tao, Marchal, Patricia, Jost, Bernard, Wissler, Manuela, Maurer, Ulrich, Kastner, Philippe, Chan, Susan, Charvet, Céline
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2021
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8092604/
https://ncbi.nlm.nih.gov/pubmed/33893236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2023172118
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