The Pharmacodynamic-Toxicodynamic Relationship of AUC and C(max) in Vancomycin-Induced Kidney Injury in an Animal Model

Vancomycin induces exposure-related acute kidney injury. However, the pharmacokinetic-toxicodynamic (PK-TD) relationship remains unclear. Sprague-Dawley rats received intravenous (i.v.) vancomycin doses of 300 mg/kg/day and 400 mg/kg/day, divided into once-, twice-, three-times-, or four-times-daily...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Avedissian, Sean N., Pais, Gwendolyn, Liu, Jiajun, O’Donnell, J. Nicholas, Lodise, Thomas P., Neely, Michael, Prozialeck, Walter C., Lamar, Peter C., Becher, Leighton, Scheetz, Marc H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2021
Assuntos:
Experimental Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8092494/
https://ncbi.nlm.nih.gov/pubmed/33318004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01945-20
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