1568. The Pharmacodynamic–Toxicodynamic Relationship of AUC and CMAX in Vancomycin-Induced Kidney Injury

BACKGROUND: Vancomycin induces exposure-related acute kidney injury [AKI]; yet the toxicodynamic (TD) driver for toxicity (area under the curve [AUC], vs. maximum concentration [CMAX] vs. trough concentrations [CMIN]) remains unclear. Recent vancomycin guidelines now recommend monitoring AUC over tr...

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Detalhes bibliográficos
Publicado no:Open Forum Infect Dis
Main Authors: Avedissian, Sean N, Pais, Gwendolyn M, Liu, Jiajun, O’Donnell, J Nicholas, Lodise, Thomas, Prozialeck, Walter, Lamar, Peter, Neely, Michael, Scheetz, Marc H
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6809992/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ofid/ofz360.1432
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