Evaluation of Vancomycin Exposures Associated with Elevations in Novel Urinary Biomarkers of Acute Kidney Injury in Vancomycin-Treated Rats

Vancomycin has been associated with acute kidney injury (AKI). However, the pharmacokinetic/toxicodynamic relationship for AKI is not well defined. Allometrically scaled vancomycin exposures were used to assess the relationship between vancomycin exposure and AKI. Male Sprague-Dawley rats received c...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Rhodes, Nathaniel J., Prozialeck, Walter C., Lodise, Thomas P., Venkatesan, Natarajan, O'Donnell, J. Nicholas, Pais, Gwendolyn, Cluff, Cameron, Lamar, Peter C., Neely, Michael N., Gulati, Anil, Scheetz, Marc H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2016
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5038238/
https://ncbi.nlm.nih.gov/pubmed/27431226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00591-16
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