Twenty-four hour pharmacokinetic relationships for intravenous vancomycin and novel urinary biomarkers of acute kidney injury in a rat model

OBJECTIVES: To identify the pharmacokinetic (PK) and toxicodynamic (TD) relationship for vancomycin-induced kidney injury. METHODS: Male Sprague–Dawley rats received intravenous (iv) vancomycin. Doses ranging from 150 mg/kg/day to 400 mg/kg/day were administered as a single or twice-daily injection...

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Detalhes bibliográficos
Publicado no:J Antimicrob Chemother
Main Authors: Avedissian, Sean N, Pais, Gwendolyn M, O’Donnell, J Nicholas, Lodise, Thomas P, Liu, Jiajun, Prozialeck, Walter C, Joshi, Medha D, Lamar, Peter C, Becher, Leighton, Gulati, Anil, Hope, William, Scheetz, Marc H
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6640290/
https://ncbi.nlm.nih.gov/pubmed/31065686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkz167
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