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Functional and genetic determinants of mutation rate variability in regulatory elements of cancer genomes

BACKGROUND: Cancer genomes are shaped by mutational processes with complex spatial variation at multiple scales. Entire classes of regulatory elements are affected by local variations in mutation frequency. However, the underlying mechanisms with functional and genetic determinants remain poorly und...

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Bibliografski detalji
Izdano u:Genome Biol
Glavni autori: Lee, Christian A., Abd-Rabbo, Diala, Reimand, Jüri
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2021
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8091793/
https://ncbi.nlm.nih.gov/pubmed/33941236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-021-02318-x
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