Deep sequencing of pre-translational mRNPs reveals hidden flux through evolutionarily conserved alternative splicing nonsense-mediated decay pathways

BACKGROUND: Alternative splicing, which generates multiple mRNA isoforms from single genes, is crucial for the regulation of eukaryotic gene expression. The flux through competing splicing pathways cannot be determined by traditional RNA-Seq, however, because different mRNA isoforms can have widely...

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Bibliografski detalji
Izdano u:Genome Biol
Glavni autori: Kovalak, Carrie, Donovan, Scott, Bicknell, Alicia A., Metkar, Mihir, Moore, Melissa J.
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2021
Teme:
Research
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8091538/
https://ncbi.nlm.nih.gov/pubmed/33941243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-021-02309-y
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