Deep sequencing of pre-translational mRNPs reveals hidden flux through evolutionarily conserved alternative splicing nonsense-mediated decay pathways

BACKGROUND: Alternative splicing, which generates multiple mRNA isoforms from single genes, is crucial for the regulation of eukaryotic gene expression. The flux through competing splicing pathways cannot be determined by traditional RNA-Seq, however, because different mRNA isoforms can have widely...

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Detalhes bibliográficos
Publicado no:Genome Biol
Main Authors: Kovalak, Carrie, Donovan, Scott, Bicknell, Alicia A., Metkar, Mihir, Moore, Melissa J.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2021
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8091538/
https://ncbi.nlm.nih.gov/pubmed/33941243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-021-02309-y
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