Deep sequencing of pre-translational mRNPs reveals hidden flux through evolutionarily conserved alternative splicing nonsense-mediated decay pathways

BACKGROUND: Alternative splicing, which generates multiple mRNA isoforms from single genes, is crucial for the regulation of eukaryotic gene expression. The flux through competing splicing pathways cannot be determined by traditional RNA-Seq, however, because different mRNA isoforms can have widely...

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Udgivet i:Genome Biol
Main Authors: Kovalak, Carrie, Donovan, Scott, Bicknell, Alicia A., Metkar, Mihir, Moore, Melissa J.
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2021
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8091538/
https://ncbi.nlm.nih.gov/pubmed/33941243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-021-02309-y
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