APOL1 risk variants affect podocyte lipid homeostasis and energy production in focal segmental glomerulosclerosis

Lipotoxicity was recently reported in several forms of kidney disease, including focal segmental glomerulosclerosis (FSGS). Susceptibility to FSGS in African Americans is associated with the presence of genetic variants of the Apolipoprotein L1 gene (APOL1) named G1 and G2. If and how endogenous APO...

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Detalhes bibliográficos
Publicado no:Hum Mol Genet
Main Authors: Ge, Mengyuan, Molina, Judith, Ducasa, G Michelle, Mallela, Shamroop K, Varona Santos, Javier, Mitrofanova, Alla, Kim, Jin-Ju, Liu, Xiaochen, Sloan, Alexis, Mendez, Armando J, Banerjee, Santanu, Liu, Shaoyi, Szeto, Hazel H, Shin, Myung K, Hoek, Maarten, Kopp, Jeffrey B, Fontanesi, Flavia, Merscher, Sandra, Fornoni, Alessia
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2021
Assuntos:
General Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8091039/
https://ncbi.nlm.nih.gov/pubmed/33517446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddab022
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