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Discoidin domain receptor 1 activation links extracellular matrix to podocyte lipotoxicity in Alport syndrome

BACKGROUND: Discoidin domain receptor 1 (DDR1) is a receptor tyrosine kinase that is activated by collagens that is involved in the pathogenesis of fibrotic disorders. Interestingly, de novo production of the collagen type I (Col I) has been observed in Col4a3 knockout mice, a mouse model of Alport...

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Publicado en:EBioMedicine
Autores principales: Kim, Jin-Ju, David, Judith M., Wilbon, Sydney S., Santos, Javier V., Patel, Devang M., Ahmad, Anis, Mitrofanova, Alla, Liu, Xiaochen, Mallela, Shamroop K., Ducasa, Gloria M., Ge, Mengyuan, Sloan, Alexis J., Al-Ali, Hassan, Boulina, Marcia, Mendez, Armando J., Contreras, Gabriel N., Prunotto, Marco, Sohail, Anjum, Fridman, Rafael, Miner, Jeffrey H., Merscher, Sandra, Fornoni, Alessia
Formato: Artigo
Lenguaje:Inglês
Publicado: Elsevier 2020
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7750578/
https://ncbi.nlm.nih.gov/pubmed/33340991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2020.103162
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