APOL1 risk variants affect podocyte lipid homeostasis and energy production in focal segmental glomerulosclerosis

Lipotoxicity was recently reported in several forms of kidney disease, including focal segmental glomerulosclerosis (FSGS). Susceptibility to FSGS in African Americans is associated with the presence of genetic variants of the Apolipoprotein L1 gene (APOL1) named G1 and G2. If and how endogenous APO...

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Dades bibliogràfiques
Publicat a:Hum Mol Genet
Autors principals: Ge, Mengyuan, Molina, Judith, Ducasa, G Michelle, Mallela, Shamroop K, Varona Santos, Javier, Mitrofanova, Alla, Kim, Jin-Ju, Liu, Xiaochen, Sloan, Alexis, Mendez, Armando J, Banerjee, Santanu, Liu, Shaoyi, Szeto, Hazel H, Shin, Myung K, Hoek, Maarten, Kopp, Jeffrey B, Fontanesi, Flavia, Merscher, Sandra, Fornoni, Alessia
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2021
Matèries:
General Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8091039/
https://ncbi.nlm.nih.gov/pubmed/33517446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddab022
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