APOL1 risk variants affect podocyte lipid homeostasis and energy production in focal segmental glomerulosclerosis

Lipotoxicity was recently reported in several forms of kidney disease, including focal segmental glomerulosclerosis (FSGS). Susceptibility to FSGS in African Americans is associated with the presence of genetic variants of the Apolipoprotein L1 gene (APOL1) named G1 and G2. If and how endogenous APO...

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Veröffentlicht in:Hum Mol Genet
Hauptverfasser: Ge, Mengyuan, Molina, Judith, Ducasa, G Michelle, Mallela, Shamroop K, Varona Santos, Javier, Mitrofanova, Alla, Kim, Jin-Ju, Liu, Xiaochen, Sloan, Alexis, Mendez, Armando J, Banerjee, Santanu, Liu, Shaoyi, Szeto, Hazel H, Shin, Myung K, Hoek, Maarten, Kopp, Jeffrey B, Fontanesi, Flavia, Merscher, Sandra, Fornoni, Alessia
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2021
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General Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8091039/
https://ncbi.nlm.nih.gov/pubmed/33517446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddab022
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