ATP-binding cassette A1 deficiency causes cardiolipin-driven mitochondrial dysfunction in podocytes

Fibroblasts from patients with Tangier disease carrying ATP-binding cassette A1 (ABCA1) loss-of-function mutations are characterized by cardiolipin accumulation, a mitochondrial-specific phospholipid. Suppression of ABCA1 expression occurs in glomeruli from patients with diabetic kidney disease (DKD...

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Vydáno v:J Clin Invest
Hlavní autoři: Ducasa, G. Michelle, Mitrofanova, Alla, Mallela, Shamroop K., Liu, Xiaochen, Molina, Judith, Sloan, Alexis, Pedigo, Christopher E., Ge, Mengyuan, Santos, Javier Varona, Hernandez, Yanio, Kim, Jin-Ju, Maugeais, Cyrille, Mendez, Armando J., Nair, Viji, Kretzler, Matthias, Burke, George W., Nelson, Robert G., Ishimoto, Yu, Inagi, Reiko, Banerjee, Santanu, Liu, Shaoyi, Szeto, Hazel H., Merscher, Sandra, Fontanesi, Flavia, Fornoni, Alessia
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2019
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6668702/
https://ncbi.nlm.nih.gov/pubmed/31329164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI125316
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