The Increased Accumulation of Staphylococcus aureus Virulence Factors Is Maximized in a purR Mutant by the Increased Production of SarA and Decreased Production of Extracellular Proteases

Mutation of purR was previously shown to enhance the virulence of Staphylococcus aureus in a murine sepsis model, and this cannot be fully explained by increased expression of genes within the purine biosynthesis pathway. Rather, the increased production of specific S. aureus virulence factors, incl...

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Veröffentlicht in:Infect Immun
Hauptverfasser: Alkam, Duah, Jenjaroenpun, Piroon, Ramirez, Aura M., Beenken, Karen E., Spencer, Horace J., Smeltzer, Mark S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2021
Schlagworte:
Molecular Pathogenesis
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8090970/
https://ncbi.nlm.nih.gov/pubmed/33468580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00718-20
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