Endonasal CNS Delivery System for Blood-Brain Barrier Impermeant Therapeutic Oligonucleotides Using Heterotopic Mucosal Engrafting

The most significant obstacle in the treatment of neurological disorders is the blood-brain barrier (BBB), which prevents 98% of all potential neuropharmaceuticals from reaching the central nervous system (CNS). Brain derived neurotrophic factor (BDNF) is one of the most intensely studied targets in...

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Vydáno v:Front Pharmacol
Hlavní autoři: Pawar, Grishma, Parayath, Neha N., Sharma, Aditya A., Coito, Carlos, Khorkova, Olga, Hsiao, Jane, Curry, William T., Amiji, Mansoor M., Bleier, Benjamin S.
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2021
Témata:
Pharmacology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8090932/
https://ncbi.nlm.nih.gov/pubmed/33953687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2021.660841
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